Caution! Analyze transcripts from conditional knockout alleles
نویسندگان
چکیده
منابع مشابه
Generation of conditional knockout alleles for PRL-3☆
Phosphatase of regenerating liver-3 (PRL-3) is a member of the protein tyrosine phosphatase (PTP) superfamily and is highly expressed in cancer metastases. For better understanding of the role of PRL-3 in tumor metastasis, we applied a rapid and efficient method for generating PRL-3 floxed mice and investigated its phenotypes. A BAC retrieval strategy was applied to construct the PRL-3 conditio...
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Protein phosphatase 2A (PP2A) is one of the most abundant serine/threonine phosphatases, with a critical role in embryonic development and human disease. There are two isoforms of the catalytic subunit of PP2A, Ppp2ca and Ppp2cb. Null mutation of Ppp2ca leads to early embryonic lethality at E6.5, hindering functional study of PP2A beyond this stage. We generated conditional null alleles of Ppp2...
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ژورنال
عنوان ژورنال: Transgenic Research
سال: 2008
ISSN: 0962-8819,1573-9368
DOI: 10.1007/s11248-008-9237-9